Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Golgi apparatus
Endoplasmic reticulum
Endosome
Cell surface
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Precision
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Recovery
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Linearity
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References
1.
"Molecular characterization of the mouse Asp1 gene, a homolog of the human ASP1 (Down Syndrome region aspartyl protease)." Choi D.K.
,
Sugano S.
,
Sakaki Y.
Submitted (1999-12) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [MRNA]